Ketamine

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Pain management

Low doses of ketamine may reduce morphine use, nausea, and vomiting after surgery.Ketamine has similar efficacy to opioids in a hospital emergency department setting for management of acute pain and for control of procedural pain.

It may also be used as an intravenous analgesic with opiates to manage otherwise intractable pain, particularly if this pain is neuropathic. It has the added benefit of counteracting spinal sensitization or wind-up phenomena experienced with chronic pain. At these doses, the psychotropic side effects are less apparent and well managed with benzodiazepines. Ketamine is an analgesic that is most effective when used alongside a low-dose opioid; because, A review article in 2013 concluded, “despite limitations in the breadth and depth of data available, there is evidence that ketamine may be a viable option for treatment-refractory cancer pain”. Order Ketamine Powder Online.

A 2013 systematic review found only low-quality evidence to support the use of ketamine for CRPS.Anesthesia

Uses as an anesthetic:

• Anesthesia in children, as the sole anesthetic for minor procedures or as an induction agent followed by muscle relaxant and tracheal intubation
• Asthmatics or people with chronic obstructive airway disease
• As a sedative for physically painful procedures in emergency departments
• Emergency surgery in field conditions in war zones
• To supplement spinal or epidural anesthesia/analgesia using low doses

A 2011 clinical practice guideline supports the use of ketamine as a dissociative sedative in emergency medicine. It is the drug of choice for people in traumatic shock who are at risk of hypotension. Low blood pressure is harmful in people with severe head injury[ and ketamine is least likely to cause low blood pressure, often even able to prevent it.

The effect of ketamine on the respiratory and circulatory systems is different from that of other anesthetics. When used at anesthetic doses, it will usually stimulate rather than depress the circulatory system.[36] It is sometimes possible to perform ketamine anesthesia without protective measures to the airways.